Age-associated changes in excitation-contraction coupling are more prominent in ventricular myocytes from male rats than in myocytes from female rats. Cengage Learning. OVX of female rats led to larger infarct sizes, but estrogen supplementation attenuated this response.
While the mechanisms for the observed sex differences in genetic HCM models are not well understood, they should be taken into account when choosing a genetic model of the disease. An evaluation of more than opposite-sex dizygotic twin pairs who met lifetime criteria for MDD showed that fatigue, hypersomnia, and psychomotor retardation were more prevalent in females, while insomnia and agitation were more likely to occur in males.
Figure 2. Much remains to be learned about how sex influences mitochondrial number and function in the heart; interactions among approximately 1, genes contribute to normal function. Leinwand LA. Post ischemic function was decreased in Tg males. Research in Psychotherapy.
The role of sex in cardiac function and disease. Eur J Pharmacol.
Each of these currents, particularly those mediated by calcium and potassium channels, exhibits significant sexual dimorphisms. Hypertrophic response is similar after 6 weeks. Harvey , 1 Jane F. Estrogen receptor-beta prevents cardiac fibrosis.