The evolution of sex-biased gene expression is thought to mediate the effects of sexual antagonism and allow for achievement of sex-specific fitness. Otake, T. These contradicting observations can be reconciled if the mechanism of X upregulation does not act chromosome-wide but specifically regulates dosage-sensitive genes.
National Center for Biotechnology InformationU. Nature : — Genetic sex determination mechanisms and evolution. Although strategies differ, dosage-compensation mechanisms have been found in mammals, Drosophilaand C.
Chromosomal assignments by SSCP are indicated below each bar. Importantly, an inverse correlation exists between the copy number variation in Sly and Rmby ChrY multicopy genes and the number of significantly up-regulated genes in immune cells, thereby providing a link between copy number variation and the ChrY genetic element exerting regulatory properties.
Development— The overall trends were the same when we included all biased genes in the analysis Figure S4C and D. Animals that initially produce gametes of one sex, followed by full differentiation as male or female.
What are Sex Chromosomes? But homomorphic chromosomes undergo evolutionary processes by homologous recombination and mutation. Acetosain which multiple sex chromosomes appeared independently in European R. Cell Cycle. Abstract 99 References Related Papers.
Single-end bp sequencing was performed using the Illumina HiSeq Lutnesky, M. To understand how evolutionary pressures that maintain macrosynteny of sex-biased genes differ between the X and autosomes, we compared the conservation of chromosomal location for genes with male, female, and nonbiased expression.